@article {11,
	title = {NFATc3 is required for intermittent hypoxia-induced hypertension},
	journal = {American Journal of Physiology-heart and Circulatory Physiology},
	volume = {294},
	year = {2008},
	pages = {H2382{\textendash}H2390},
	abstract = {{Sleep apnea, defined as intermittent respiratory arrest during sleep, is associated with increased incidence of hypertension and peripheral vascular disease. Exposure of rodents to brief periods of intermittent hypercarbia/hypoxia (H-IH) during sleep mimics the cyclical hypoxia-normoxia of sleep apnea. Endothelin-1, an upstream activator of nuclear factor of activated T cells (NFAT), is increased during H-IH. Therefore, we hypothesized that NFATc3 is activated by H-IH and is required for H-IH-induced hypertension. Consistent with this hypothesis, we found that H-IH (20 brief exposures per hour to 5\% O-2-5\% CO2 for 7 h/day) induces systemic hypertension in mice [mean arterial pressure (MAP) = 97 +/- 2 vs. 124 +/- 2 mmHg, P < 0.05},
	doi = {10.1152/ajpheart.00132.2008},
	author = {de Frutos Garc{\'\i}a , Sergio and Duling, Laura and Al{\`o}, Dominique and Berry, Tammy and Jackson-Weaver, Olan and Walker, Mary and Kanagy, Nancy and Gonzalez-Bosc, Laura V}
}
