@article {49,
	title = {Diversity of Aplochiton Fishes (Galaxiidea) and the Taxonomic Resurrection of A. marinus},
	journal = {PLoS One},
	year = {2013},
	chapter = {e71577},
	abstract = {Aplochiton is a small genus of galaxiid fishes endemic to Patagonia and the Falkland Islands whose taxonomy is insufficiently resolved. Recent genetic analyses confirmed the existence of only two closely related species, Aplochiton taeniatus and Aplochiton zebra, while a third controversial species, Aplochiton marinus, remained lost to synonymy with A. taeniatus. Using an integrative taxonomy framework, we studied original samples and published sequences from a broad range in western Patagonia and the Falkland Islands, and generated robust species hypotheses based on single-locus (Cytochrome Oxidase subunit I; COI) species-delineation methods and known diagnostic morphological characters analyzed in a multivariate context. Results revealed three distinct evolutionary lineages that morphologically resemble, in important respects, existing nominal species descriptions. Interestingly, the lineage associated with A. marinus was unambiguously identifiable (100\% accuracy) both from the genetic and morphological viewpoints. In contrast, the morphology of A. taeniatus and A. zebra overlapped substantially, mainly due to the high variability of A. taeniatus. Discriminant function analysis aided the identification of these species with 83.9\% accuracy. Hence, for their unambiguous identification, genetic screening is needed. A. marinus has seldom been documented, and when recorded, it has always been found in sites with clear marine influence. It is possible that only A. marinus preserves a life cycle related to the sea akin to the hypothesized ancestral galaxiid. We did not find evidence of claimed diadromy in A. taeniatus or A. zebra, and, therefore, these should be regarded as freshwater species. Finally, a lack of phylogeographic patterns and overrepresentation of uncommon haplotypes suggested demographic expansions in recent evolutionary time, especially of A. zebra, in line with the hypothesis of large-scale range expansion and lineage spread in western Patagonia.},
	doi = {10.1371\%252Fjournal.pone.0071577},
	url = {http://www.plosone.org/article/info\%3Adoi\%2F10.1371\%2Fjournal.pone.0071577},
	author = {Al{\`o}, Dominique and Correa, Cristi{\'a}n and Carlos Arias and Leyla C{\'a}rdenas}
}
@article {11,
	title = {NFATc3 is required for intermittent hypoxia-induced hypertension},
	journal = {American Journal of Physiology-heart and Circulatory Physiology},
	volume = {294},
	year = {2008},
	pages = {H2382{\textendash}H2390},
	abstract = {{Sleep apnea, defined as intermittent respiratory arrest during sleep, is associated with increased incidence of hypertension and peripheral vascular disease. Exposure of rodents to brief periods of intermittent hypercarbia/hypoxia (H-IH) during sleep mimics the cyclical hypoxia-normoxia of sleep apnea. Endothelin-1, an upstream activator of nuclear factor of activated T cells (NFAT), is increased during H-IH. Therefore, we hypothesized that NFATc3 is activated by H-IH and is required for H-IH-induced hypertension. Consistent with this hypothesis, we found that H-IH (20 brief exposures per hour to 5\% O-2-5\% CO2 for 7 h/day) induces systemic hypertension in mice [mean arterial pressure (MAP) = 97 +/- 2 vs. 124 +/- 2 mmHg, P < 0.05},
	doi = {10.1152/ajpheart.00132.2008},
	author = {de Frutos Garc{\'\i}a , Sergio and Duling, Laura and Al{\`o}, Dominique and Berry, Tammy and Jackson-Weaver, Olan and Walker, Mary and Kanagy, Nancy and Gonzalez-Bosc, Laura V}
}
@article {12,
	title = {NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation},
	journal = {Journal of Biological Chemistry},
	volume = {282},
	year = {2007},
	pages = {15081{\textendash}15089},
	abstract = {Physiological responses to chronic hypoxia include polycythemia, pulmonary arterial remodeling, and vasoconstriction. Chronic hypoxia causes pulmonary arterial hypertension leading to right ventricular hypertrophy and heart failure. During pulmonary hypertension, pulmonary arteries exhibit increased expression of smooth muscle-alpha-actin and -myosin heavy chain. NFATc3 ( nuclear factor of activated T cells isoform c3), which is a Ca2+-dependent transcription factor, has been recently linked to smooth muscle phenotypic maintenance through the regulation of the expression of alpha-actin. The aim of this study was to determine if: ( a) NFATc3 is expressed in murine pulmonary arteries, ( b) hypoxia induces NFAT activation, ( c) NFATc3 mediates the up-regulation of alpha-actin during chronic hypoxia, and ( d) NFATc3 is involved in chronic hypoxia-induced pulmonary vascular remodeling. NFATc3 transcript and protein were found in pulmonary arteries. NFAT-luciferase reporter mice were exposed to normoxia ( 630 torr) or hypoxia ( 380 torr) for 2, 7, or 21 days. Exposure to hypoxia elicited a significant increase in luciferase activity and pulmonary arterial smooth muscle nuclear NFATc3 localization, demonstrating NFAT activation. Hypoxia induced up-regulation of alpha-actin and was prevented by the calcineurin/NFAT inhibitor, cyclosporin A ( 25 mg/kg/day s.c.). In addition, NFATc3 knock-out mice did not showed increased alpha-actin levels and arterial wall thickness after hypoxia. These results strongly suggest that NFATc3 plays a role in the chronic hypoxia-induced vascular changes that underlie pulmonary hypertension.},
	doi = {10.1074/jbc.M702679200},
	author = {de Frutos Garc{\'\i}a , Sergio and Spangler, Rhyannon and Al{\`o}, Dominique and Gonzalez-Bosc, Laura V}
}
@article {17,
	title = {Life history and environmental variation interact to determine effective population to census size ratio},
	journal = {Proceedings of the Royal Society B-biological Sciences},
	volume = {273},
	year = {2006},
	pages = {3065{\textendash}3073},
	abstract = {Successful recovery and sustainability of threatened and exploited species depends in part on retention and maintenance of genetic diversity. Theory indicates that genetic diversity is lost at a rate inversely proportional to the genetically effective population size (N-e), which is roughly equal to one-half the adult census size (N) in many organisms. However, Ne has been reported to be up to five orders of magnitude lower than N in species with life histories that result in type III survivorship (high fecundity, but heavy mortality in early life stages, e.g. bony fishes), prompting speculation that low values of Ne may be a general feature of such organisms despite sometimes vast abundances. Here, we compared Ne and the ratio N-e/N across three ecologically similar fish species from the arid southwestern United States, all with type III life histories but with differing expectations of egg and larval survivorship that correlate with the degree of human-imposed habitat fragmentation. Our study indicates that type III life history may be necessary, but this alone is insufficient to account for extraordinarily low values of N-e/N. Rather, life history interacts with environmentally imposed mortality to determine the rate and magnitude of change in genetic diversity in these desert fish species.},
	doi = {10.1098/rspb.2006.3677},
	author = {Turner, Thomas F. and Osborne, Megan J. and Moyer, Gregory R. and Benavides, Melissa A. and Al{\`o}, Dominique}
}
@article {31,
	title = {Effects of habitat fragmentation on effective population size in the endangered Rio Grande silvery minnow},
	journal = {Conservation Biology},
	volume = {19},
	year = {2005},
	chapter = {1138--1148},
	author = {Al{\`o}, Dominique and Turner, Thomas F.}
}
